The AAPS Journal - Volume 11 Number 2, Jun 2009 Articles

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Volume 11 Number 2, Jun 2009

The AAPS Journal

Volume 11 Number 2, Jun 2009

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Role of Physiological Intestinal Water in Oral Absorption
Author(s): Steven Sutton

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
The H2 Receptor Antagonist Nizatidine is a P-Glycoprotein Substrate: Characterization of its Intestinal Epithelial Cell Efflux Transport
Author(s): Arik Dahan; Hairat Sabit; Gordon Amidon
AAPS–FIP Summary Workshop Report: Pharmacogenetics in Individualized Medicine: Methods, Regulatory, and Clinical Applications
Author(s): Majid Moridani; Anke-Hilse Maitland-van der Zee; Hitoshi Sasaki; Ross McKinnon; Lawrence Fleckenstein; Vinod Shah
Mechanistic Approaches to Predicting Oral Drug Absorption
Author(s): Weili Huang; Sau Lee; Lawrence Yu

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Population-Based Mechanistic Prediction of Oral Drug Absorption
Author(s): Masoud Jamei; David Turner; Jiansong Yang; Sibylle Neuhoff; Sebastian Polak; Amin Rostami-Hodjegan; Geoffrey Tucker

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Workshop Report and Follow-Up—AAPS Workshop on Current Topics in GLP Bioanalysis: Assay Reproducibility for Incurred Samples—Implications of Crystal City Recommendations
Author(s): Douglas Fast; Marian Kelley; C. Viswanathan; Jacqueline O’Shaughnessy; S. King; Ajai Chaudhary; Russell Weiner; Anthony DeStefano; Daniel Tang
Therapeutic Paint of Cidofovir/Sucralfate Gel Combination Topically Administered by Spraying for Treatment of orf virus Infections
Author(s): Fabio Sonvico; Gaia Colombo; Laura Gallina; Fabrizio Bortolotti; Alessandra Rossi; Colin McInnes; Gina Massimo; Paolo Colombo; Alessandra Scagliarini
Effects of Drug Transporters on Volume of Distribution
Author(s): Anita Grover; Leslie Benet
Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development
Author(s): Masato Chiba; Yasuyuki Ishii; Yuichi Sugiyama

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
A Review of Imaging Agent Development
Author(s): Eric Agdeppa; Mary Spilker

In Themed Issue: Imaging in Drug Development and Therapeutics
Peptide Kappa Opioid Receptor Ligands: Potential for Drug Development
Author(s): Jane Aldrich; Jay McLaughlin

In Themed Issue: NIDA Symposium: Drugs of Abuse: Special Topics in Drug Development
Predicting Drug–Drug Interactions: An FDA Perspective
Author(s): Lei Zhang; Yuanchao Zhang; Ping Zhao; Shiew-Mei Huang

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data
Author(s): Viera Lukacova; Walter Woltosz; Michael Bolger

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
A Multi-Tiered Analytical Approach For the Analysis and Quantitation of High-Molecular-Weight Aggregates in a Recombinant Therapeutic Glycoprotein
Author(s): Heather Hughes; Charles Morgan; Elizabeth Brunyak; Kristen Barranco; Emily Cohen; Tim Edmunds; Karen Lee
Measuring Endocannabinoid Hydrolysis: Refining our Tools and Understanding
Author(s): William Marrs; Nephi Stella

In Themed Issue: NIDA Symposium: Drugs of Abuse: Drug Development and Cannabinoids
Inhibitors of Endocannabinoid-Metabolizing Enzymes Reduce Precipitated Withdrawal Responses in THC-Dependent Mice
Author(s): Joel Schlosburg; Brittany Carlson; Divya Ramesh; Rehab Abdullah; Jonathan Long; Benjamin Cravatt; Aron Lichtman

In Themed Issue: NIDA Symposium: Drugs of Abuse: Drug Development and Cannabinoids
Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine
Author(s): Michael Bolger; Viera Lukacova; Walter Woltosz

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Handling Data Below the Limit of Quantification in Mixed Effect Models
Author(s): Martin Bergstrand; Mats Karlsson
Structure-Based Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes
Author(s): Haiyan Li; Jin Sun; Xiaofan Sui; Zhongtian Yan; Yinghua Sun; Xiaohong Liu; Yongjun Wang; Zhonggui He
An Investigation into the Importance of “Very Rapid Dissolution” Criteria for Drug Bioequivalence Demonstration using Gastrointestinal Simulation Technology
Author(s): Ivan Kovačevi; Jelena Parojči; Marija Tubi-Grozdanis; Peter Langguth

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
“Fit-for-Purpose” Method Validation and Application of a Biomarker (C-terminal Telopeptides of Type 1 Collagen) in Denosumab Clinical Studies
Author(s): Jin Wang; Jean Lee; Daniel Burns; David Doherty; Laura Brunner; Mark Peterson; Binodh DeSilva

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