The AAPS Journal - Volume 11 Number 3, Sep 2009 Articles

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Volume 11 Number 3, Sep 2009

The AAPS Journal

Volume 11 Number 3, Sep 2009

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PEG-conjugated PAMAM Dendrimers Mediate Efficient Intramuscular Gene Expression
Author(s): Rong Qi; Yu Gao; Yin Tang; Rui-Rui He; Tao-Le Liu; Yun He; Sheng Sun; Bo-Yu Li; Yang-Bing Li; George Liu
Advancement of Structure-Activity Relationship of Multidrug Resistance-Associated Protein 2 Interactions
Author(s): Li Xing; Yiding Hu; Yurong Lai
Structure–Activity Relationships of Tariquidar Analogs as Multidrug Resistance Modulators
Author(s): Ilza Pajeva; Michael Wiese
Role of Glycosylation in Conformational Stability, Activity, Macromolecular Interaction and Immunogenicity of Recombinant Human Factor VIII
Author(s): Matthew Kosloski; Razvan Miclea; Sathy Balu-Iyer
Inhibitors of the FcRn:IgG Protein–Protein Interaction
Author(s): Susan Low; Adam Mezo

In Themed Issue: Investigation of the role of FcRn on the absorption, distribution, and elimination of IgG and Albumin
In Vitro Considerations to Support Bioequivalence of Locally Acting Drugs in Dry Powder Inhalers for Lung Diseases
Author(s): Sau Lee; Wallace Adams; Bing Li; Dale Conner; Badrul Chowdhury; Lawrence Yu
Influence of the Molecular Weight of Bioreducible Oligoethylenimine Conjugates on the Polyplex Transfection Properties
Author(s): Haijun Yu; Verena Russ; Ernst Wagner
Endpoints and Analyses to Discern Disease-Modifying Drug Effects in Early Parkinson’s Disease
Author(s): Venkatesh Bhattaram; Ohidul Siddiqui; Leonard Kapcala; Jogarao Gobburu
Prediction of Biliary Excretion in Rats and Humans Using Molecular Weight and Quantitative Structure–Pharmacokinetic Relationships
Author(s): Xinning Yang; Yash Gandhi; David Duignan; Marilyn Morris
Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles
Author(s): Rania Salama; Leigh Ladd; Hak-Kim Chan; Daniela Traini; Paul Young
Prediction of Deleterious Non-synonymous Single-Nucleotide Polymorphisms of Human Uridine Diphosphate Glucuronosyltransferase Genes
Author(s): Yuan Di; Eli Chan; Ming Wei; Jun-Ping Liu; Shu-Feng Zhou
Insights into the Substrate Specificity, Inhibitors, Regulation, and Polymorphisms and the Clinical Impact of Human Cytochrome P450 1A2
Author(s): Shu-Feng Zhou; Li-Ping Yang; Zhi-Wei Zhou; Ya-He Liu; Eli Chan
Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?
Author(s): Jayaraj Ravindran; Sahdeo Prasad; Bharat Aggarwal

In Themed Issue: Natural Products as Therapeutic Modulators
Investigation of the Influence of FcRn on the Distribution of IgG to the Brain
Author(s): Amit Garg; Joseph Balthasar

In Themed Issue: Investigation of the role of FcRn on the absorption, distribution, and elimination of IgG and Albumin
A Step-wise Approach for Transfer of Immunogenicity Assays during Clinical Drug Development
Author(s): Suzanna Tatarewicz; Michael Moxness; Dohan Weeraratne; Lei Zhou; Michael Hale; Steven Swanson; Narendra Chirmule
Population Pharmacodynamic Parameter Estimation from Sparse Sampling: Effect of Sigmoidicity on Parameter Estimates
Author(s): Sudhakar Pai; Suzette Girgis; Vijay Batra; Ihab Girgis
Structure–Activity Relationships and Quantitative Structure–Activity Relationships for Breast Cancer Resistance Protein (ABCG2)
Author(s): Yash Gandhi; Marilyn Morris
Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics: Problems and Solutions
Author(s): Radojka Savic; Mats Karlsson
Statistical Considerations for Assessment of Bioanalytical Incurred Sample Reproducibility
Author(s): David Hoffman
Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines
Author(s): Thomas Chang

In Themed Issue: Natural Products as Therapeutic Modulators
Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data
Author(s): Tycho Heimbach; Suresh Lakshminarayana; Wenyu Hu; Handan He

In Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Technical Pitfalls and Improvements for High-speed Screening and QSAR Analysis to Predict Inhibitors of the Human Bile Salt Export Pump (ABCB11/BSEP)
Author(s): Hikaru Saito; Masako Osumi; Hiroyuki Hirano; Wangsoo Shin; Ryota Nakamura; Toshihisa Ishikawa
Evaluation of an Extended Grid Method for Estimation Using Nonparametric Distributions
Author(s): Radojka Savic; Mats Karlsson
Strategy to Prevent Drug-Related Hypersensitivity in Folate-Targeted Hapten Immunotherapy of Cancer
Author(s): Yingjuan Lu; Patrick Klein; Elaine Westrick; Le-Cun Xu; Hari Santhapuram; Alicia Bloomfield; Stephen Howard; Iontcho Vlahov; P. Ellis; Philip Low; Christopher Leamon

In Themed Issue: Critical Variables in the In Vitro and In Vivo Performance of Parenteral Sustained Release Products

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