The AAPS Journal - Volume 11 Number 4, Dec 2009 Articles

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Volume 11 Number 4, Dec 2009

The AAPS Journal

Volume 11 Number 4, Dec 2009

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Lipidic Systems for In Vivo siRNA Delivery
Author(s): Sherry Wu; Nigel McMillan

In Themed Issue: siRNA and microRNA: From Target Validation to Therapy
Evaluation of Agile Designs in First-in-Human (FIH) Trials—A Simulation Study
Author(s): Itay Perlstein; James Bolognese; Rajesh Krishna; John Wagner

In Themed Issue: Quantitative Pharmacology, a Roadmap for Rational, Model-Based Drug Development
Bioequivalence; Its History, Practice, and Future
Author(s): Kamal Midha; Gordon McKay

In Themed Issue: Pharmacokinetics, Biopharmaceutics and Bioequivalence: History and Perspectives
Nonviral Gene Delivery: Principle, Limitations, and Recent Progress
Author(s): Mohammed Al-Dosari; Xiang Gao

In Themed Issue: Emerging Drug Delivery Technologies
Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs
Author(s): Arik Dahan; Jonathan Miller; Gordon Amidon

In Themed Issue: Pharmacokinetics, Biopharmaceutics and Bioequivalence: History and Perspectives
Therapeutic MicroRNA Strategies in Human Cancer
Author(s): Chunsheng Li; Yi Feng; George Coukos; Lin Zhang

In Themed Issue: siRNA and microRNA: From Target Validation to Therapy
Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations
Author(s): Francesca Borrelli; Angelo Izzo

In Themed Issue: Natural Products as Therapeutic Modulators
MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications
Author(s): Jeffrey DeSano; Liang Xu

In Themed Issue: siRNA and microRNA: From Target Validation to Therapy
Solid Lipid Budesonide Microparticles for Controlled Release Inhalation Therapy
Author(s): Matteo Mezzena; Santo Scalia; Paul Young; Daniela Traini
In Vitro Cutaneous Application of ISCOMs on Human Skin Enhances Delivery of Hydrophobic Model Compounds Through the Stratum Corneum
Author(s): Henriette Madsen; Peter Ifversen; Flemming Madsen; Birger Brodin; Ingrid Hausser; Hanne Nielsen
Pharmacokinetic and Pharmacodynamic Modeling of a Monoclonal Antibody Antagonist of Glucagon Receptor in Male ob/ob Mice
Author(s): Yvonne Lau; Peiming Ma; Leonid Gibiansky; Renee Komorowski; Jin Wang; George Wang; Hai Yan; Murielle Véniant; Tarundeep Kakkar
Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging
Author(s): Lei Zhang; Faquan Yu; Adam Cole; Beata Chertok; Allan David; Jingkang Wang; Victor Yang
Characterization of Nanoporous Surfaces as Templates for Drug Delivery Devices
Author(s): Ashish Rastogi; Tanushree Bose; Marc Feldman; Devang Patel; Salomon Stavchansky
Critical Factors Influencing the In Vivo Performance of Long-acting Lipophilic Solutions—Impact on In Vitro Release Method Design
Author(s): Susan Weng Larsen; Claus Larsen

In Themed Issue: Critical Variables in the In Vitro and In Vivo Performance of Parenteral Sustained Release Products
Erratum to: Characterization of Nanoporous Surfaces as Templates for Drug Delivery Devices
Author(s): Ashish Rastogi; Tanushree Bose; Marc Feldman; Devang Patel; Salomon Stavchansky

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