The AAPS Journal - Volume 12 Number 3, Sep 2010 Articles

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The AAPS Journal

Volume 12 Number 3, Sep 2010

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Successes Achieved and Challenges Ahead in Translating Biomarkers into Clinical Applications
Author(s): Greg Tesch; Shashi Amur; John Schousboe; Jeffrey Siegel; Lawrence Lesko; Jane Bai
Ocular Drug Delivery
Author(s): Ripal Gaudana; Hari Ananthula; Ashwin Parenky; Ashim Mitra

In Themed Issue: Established Drug Delivery Technologies-Successes and Challenges
Online Monitoring of PLGA Microparticles Formation Using Lasentec Focused Beam Reflectance (FBRM) and Particle Video Microscope (PVM)
Author(s): Ahmed Zidan; Ziyaur Rahman; Mansoor Khan
DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles
Author(s): Yong Zhang; Meirong Huo; Jianping Zhou; Aifeng Zou; Weize Li; Chengli Yao; Shaofei Xie
Hemopressin and Other Bioactive Peptides from Cytosolic Proteins: Are These Non-Classical Neuropeptides?
Author(s): Julia Gelman; Lloyd Fricker

In Themed Issue: Fishing for the Hidden Proteome in Health and Disease: Focus on Drug Abuse
AIDS Treatment with Novel Anti-HIV Compounds Improved by Nanotechnology
Author(s): Xiaowei Ma; Dongliang Wang; Yan Wu; Rodney Ho; Lee Jia; Peixuan Guo; Liming Hu; Gengmei Xing; Yi Zeng; Xing-Jie Liang
Use of Dried Blood Spots in Drug Development: Pharmacokinetic Considerations
Author(s): Malcolm Rowland; Gary Emmons
Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4)
Author(s): Jing Zhang; Ka-Yun Ng; Paul Ho
Pulmonary Toxicity of Polysorbate-80-coated Inhalable Nanoparticles; In vitro and In vivo Evaluation
Author(s): M. Al-Hallak; Shirzad Azarmi; Chris Sun; Patrick Lai; Elmar Prenner; Wilson Roa; Raimar Löbenberg
Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library
Author(s): Kate Reilley; Marc Giulianotti; Colette Dooley; Adel Nefzi; Jay McLaughlin; Richard Houghten

In Themed Issue: Fishing for the Hidden Proteome in Health and Disease: Focus on Drug Abuse
Immunization of Guinea Pigs with Novel Hepatitis B Antigen as Nanoparticle Aggregate Powders Administered by the Pulmonary Route
Author(s): Pavan Muttil; Cecilia Prego; Lucila Garcia-Contreras; Brian Pulliam; John Fallon; Chenchen Wang; Anthony Hickey; David Edwards
Pulmonary Immunization Using Antigen 85-B Polymeric Microparticles to Boost Tuberculosis Immunity
Author(s): Dongmei Lu; Lucila Garcia-Contreras; Pavan Muttil; Danielle Padilla; Ding Xu; Jian Liu; Miriam Braunstein; David McMurray; Anthony Hickey
microRNA and Cancer
Author(s): Mengfeng Li; Jun Li; Xiaofan Ding; Mian He; Shi-Yuan Cheng

In Themed Issue: siRNA and microRNA: From Target Validation to Therapy
A Quantitative Structure–Activity Relationship for Translocation of Tripeptides via the Human Proton-Coupled Peptide Transporter, hPEPT1 (SLC15A1)
Author(s): Diana Omkvist; Simon Larsen; Carsten Nielsen; Bente Steffansen; Lars Olsen; Flemming Jørgensen; Birger Brodin
Targeting TRPV1 as an Alternative Approach to Narcotic Analgesics to Treat Chronic Pain Conditions
Author(s): Louis Premkumar

In Themed Issue: NIDA Symposium: Drugs of Abuse: Cutting-edge Research Technologies
Mechanistic Toxicokinetic Model for γ-Hydroxybutyric Acid: Inhibition of Active Renal Reabsorption as a Potential Therapeutic Strategy
Author(s): Melanie Felmlee; Qi Wang; Dapeng Cui; Samuel Roiko; Marilyn Morris
Deorphanization of Novel Peptides and Their Receptors
Author(s): Akihiko Ozawa; Iris Lindberg; Bryan Roth; Wesley Kroeze

In Themed Issue: Fishing for the Hidden Proteome in Health and Disease: Focus on Drug Abuse
Critical Variables Associated with Nonbiodegradable Osmotically Controlled Implants
Author(s): Jeremy Wright

In Themed Issue: Critical Variables in the In Vitro and In Vivo Performance of Parenteral Sustained Release Products
Species and Gender Differences Affect the Metabolism of Emodin via Glucuronidation
Author(s): Wei Liu; Lan Tang; Ling Ye; Zheng Cai; Bijun Xia; Jiajie Zhang; Ming Hu; Zhongqiu Liu
Challenges and Opportunities in Establishing Scientific and Regulatory Standards for Assuring Therapeutic Equivalence of Modified Release Products: Workshop Summary Report
Author(s): Mei-Ling Chen; Vinod Shah; Derek Ganes; Kamal Midha; James Caro; Prabu Nambiar; Mario Rocci; Avinash Thombre; Bertil Abrahamsson; Dale Conner; Barbara Davit; Paul Fackler; Colm Farrell; Suneel Gupta; Russell Katz; Mehul Mehta; Sheldon Preskorn; Gerard Sanderink; Salomon Stavchansky; Robert Temple; Yaning Wang; Helen Winkle; Lawrence Yu
Isothermal Microcalorimetry as a Quality by Design Tool to Determine Optimal Blending Sequences
Author(s): M. Al-Hallak; Shirzad Azarmi; Zhenghe Xu; Yadollah Maham; Raimar Löbenberg

In Themed Issue: Role of Dissolution in QbD and Drug Product Life Cycle
The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug
Author(s): Sandra Klein

In Themed Issue: Role of Dissolution in QbD and Drug Product Life Cycle
Mass Spectrometry Screening Reveals Peptides Modulated Differentially in the Medial Prefrontal Cortex of Rats with Disparate Initial Sensitivity to Cocaine
Author(s): Elena Romanova; Ji Lee; Neil Kelleher; Jonathan Sweedler; Joshua Gulley

In Themed Issue: Fishing for the Hidden Proteome in Health and Disease: Focus on Drug Abuse
Micro-Flow Imaging: Flow Microscopy Applied to Sub-visible Particulate Analysis in Protein Formulations
Author(s): Deepak Sharma; Dave King; Peter Oma; Clark Merchant

In Themed Issue: Methods for Detecting and Characterizing Sub-visible Particulates
Meeting Report: Applied Biopharmaceutics and Quality by Design for Dissolution/Release Specification Setting: Product Quality for Patient Benefit
Author(s): Arzu Selen; Maria Cruañes; Anette Müllertz; Paul Dickinson; Jack Cook; James Polli; Filippos Kesisoglou; John Crison; Kevin Johnson; Gordon Muirhead; Timothy Schofield; Yi Tsong
Phosphatidylinositol Containing Lipidic Particles Reduces Immunogenicity and Catabolism of Factor VIII in Hemophilia A Mice
Author(s): Aaron Peng; Robert Straubinger; Sathy Balu-Iyer

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