|
Author: Weili Huang, Sau Lee, Lawrence Yu
Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Keywords: advanced compartmental absorption and transit (ACAT) model,advanced dissolution, absorption, and metabolism (ADAM) model,compartmental model,dispersion model,oral drug absorption
Summary: the compartmental absorption and transit model; Grass model; gastrointestinal transit absorption
compartmental absorption and transit model; and advanced dissolution, absorption, and
absorption, and metabolism (ADAM) model; compartmental model; dispersion model; oral drug absorption
The AAPS Journal; Vol. 11 Number 2, Jun 2009;Published Date:05/31/2009; DOI: 10.1208/s12248-009-9098-z
|
|
Author: Yuan Zhao, Michael Abraham, Joelle Le, Anne Hersey, Chris Luscombe, Gordon Beck, Brad Sherborne, Ian Cooper
Keywords: human intestinal absorption,rate-limited step,hydrogen bonding,solubility
Summary: will have little effect on gastrointestinal absorption. of drug molecules can be useful for predicting absorption for
The absorption models overpredict the absorption of class
Pharmaceutical Research; Vol. 19 Number 10, Oct 2002;Published Date:09/30/2002; DOI: 10.1023/A:1020444330011
|
|
Author: Takanori Hironaka, Shota Itokawa, Ken-ichi Ogawara, Kazutaka Higaki, Toshikiro Kimura
Keywords: cephalexin,GITA model,oral absorption,passive diffusion,PEPT1
Summary: PEPT1 mediates the intestinal absorption of many drugs, but its contribution to oral absorption
PEPT1 to the oral absorption was calculated to be from 46% to 60% of total absorption. PEPT1 substantially contributes to oral absorption of cephalexin, around a half of total
Pharmaceutical Research; Vol. 26 Number 1, Jan 2009;Published Date:12/31/2008; DOI: 10.1007/s11095-008-9703-3
|
|
Author: Mark Ginski, Rajneesh Taneja, James Polli
Summary: dissolution-absorption relationships for fast and two-step system yielded dissolution-absorption dissolution-absorption relationships; and 3) to
The AAPS Journal; Vol. 1 Number 2, Jun 1999;Published Date:05/31/1999; DOI: 10.1208/ps010203
|
|
Author: Arne Ring, Laszlo Tothfalusi, Laszlo Endrenyi, Michael Weiss
Keywords: bioequivalence,absorption rate,extended-release,mean absorption time,relative dispersion
Summary: absorption, the profile of absorption rate often cannot be
absorption times and is abbreviated as the EX model. ence of a lag time (Tlag) for absorption, the absorption density
Pharmaceutical Research; Vol. 17 Number 5, May 2000;Published Date:04/30/2000; DOI: 10.1023/A:1007521016985
|
|
Author: Filippos Kesisoglou, Yunhui Wu
Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Keywords: absorption modeling,API properties,bioavailability,formulation,oral absorption
Summary: application of absorption modeling in understanding the effect of API properties on bioavailability. absorption modeling; API properties; bioavailability; formulation; oral absorption. tions Plus, Inc. which allows for simulation of oral absorption
The AAPS Journal; Vol. 10 Number 4, Dec 2008;Published Date:11/30/2008; DOI: 10.1208/s12248-008-9061-4
|
|
Author: Barry Hendriksen, Manuel Felix, Michael Bolger
Keywords: GIT,absorption simulation,pH solubility curve,BCS,solid-state properties,solubility screening
Summary: The purpose of this study was to examine absorption gastrointestinal tract (GIT) absorption simulation Absorption is to
The AAPS Journal; Vol. 5 Number 1, Mar 2003;Published Date:02/28/2003; DOI: 10.1208/ps050104
|
|
Author: Ryusuke Takano, Kentaro Furumoto, Koji Shiraki, Noriyuki Takata, Yoshiki Hayashi, Yoshinori Aso, Shinji Yamashita
Keywords: dissolution,in vitro–in vivo correlation,oral absorption,poorly water-soluble,rate-limiting step
Summary: Nonlinear oral absorption due to poor solubility often impedes drug development. process in oral absorption of Biopharmaceutical Classification
predict nonlinear absorption of
Pharmaceutical Research; Vol. 25 Number 10, Oct 2008;Published Date:09/30/2008; DOI: 10.1007/s11095-008-9637-9
|