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Author: A. Hatefi, B. Amsden
Keywords: camptothecin,antitumor activity,solubility,insolubility
Summary: Camptothecin has shown significant antitumor activity to lung, ovarian, breast, pancreas, and stomac camptothecin; antitumor activity; solubility; insolubility. Most recently, camptothecin and camptothecin deriva-
Pharmaceutical Research; Vol. 19 Number 10, Oct 2002;Published Date:09/30/2002; DOI: 10.1023/A:1020427227285
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Author: Shicheng Yang, Jiabi Zhu, Yu Lu, Bingwen Liang, Changzheng Yang
Keywords: camptothecin,body distribution,drug targeting,solid lipid nanoparticles,sustained release
Summary: distribution of camptothecin (CA) through incorporation into solid lipid nanoparticles (SLN) by per In vitro release characteristics of camptothecin from CA-SLN were studied at different pH media. concentration of camptothecin in organs was determined using reversed-phase high-performance liquid
Pharmaceutical Research; Vol. 16 Number 5, May 1999;Published Date:04/30/1999; DOI: 10.1023/A:1018888927852
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Author: Tian-xiang Xiang, Bradley Anderson
Keywords: cyclodextrin complexes,camptothecin analogs,parenteral formulation,lactone hydrolysis,solubilization,parenteral formulation
Summary: cally relevant more hydrophilic camptothecin analogs be- including Camptosar, topotecan, 9-amino-camptothecin, 7-(4- philic camptothecin analogs (e.g., camptothecin, 10-hydroxy-
Pharmaceutical Research; Vol. 19 Number 8, Aug 2002;Published Date:07/31/2002; DOI: 10.1023/A:1019862629357
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Author: Ann Sætern, Gøril Flaten, Martin Brandl
Keywords: liposomes,camptothecin,drug carriers,incorporation,DOTAP
Summary: approach to determine the maximum amount of camptothecin
liposomes, camptothecin, drug carriers, The pH-dependent carboxylate-lactone equilibrium of camptothecin.
AAPS PharmSciTech; Vol. 5 Number 3, Sep 2004;Published Date:08/31/2004; DOI: 10.1208/pt050340
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Author: Giridhar Thiagarajan, Abhijit Ray, Alexander Malugin, Hamidreza Ghandehari
Keywords: PAMAM dendrimer,camptothecin,drug delivery,colorectal cancer
Summary: dendrimer-camptothecin (PAMAM-CPT) conjugate and evalu- camptothecin camptothecin
Pharmaceutical Research; Online First;Published Date:06/14/2010; DOI: 10.1007/s11095-010-0179-6
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Author: Eyob Adane, Zhiwei Liu, Tian-Xiang Xiang, Bradley Anderson, Markos Leggas
Keywords: BCRP,carboxylate,lactone,OATP/Oatp,P-gp
Summary: and carboxylate forms of AR-67, a 3rd generation camptothecin
generation camptothecin analogue (1,2) currently in early
AR-67, as it does other camptothecin analogues, but AR-67
Pharmaceutical Research; Vol. 27 Number 7, Jul 2010;Published Date:06/30/2010; DOI: 10.1007/s11095-010-0137-3
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Author: Bradley Hanson, Richard Schowen, Valentino Stella
Keywords: camptothecin,phosphoryloxymethyl (POM) prodrug,hydrolysis,lactonization,kinetic solvent isotope effects,stability
Summary: POM) prodrug of camptothecin (P-CPT) P-CPT and camptothecin (CPT) was achieved with a RPHPLC assay
camptothecin; phosphoryloxymethyl (POM) pro-
Pharmaceutical Research; Vol. 20 Number 7, Jul 2003;Published Date:06/30/2003; DOI: 10.1023/A:1024410322870
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Author: Praneet Opanasopit, Masayuki Yokoyama, Masato Watanabe, Kumi Kawano, Yoshie Maitani, Teruo Okano
Keywords: anticancer agent,camptothecin,polymeric micelles,stability.
Summary: insoluble anticancer agent, camptothecin (CPT) anticancer agent; camptothecin; polymeric micelles; Camptothecin (CPT) is a potent, anticancer agent acting
Pharmaceutical Research; Vol. 21 Number 11, Nov 2004;Published Date:10/31/2004; DOI: 10.1023/B:PHAM.0000048190.53439.eb
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