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Author: Masato Chiba, Yasuyuki Ishii, Yuichi Sugiyama
Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Keywords: hepatic clearance,human hepatocytes,human PK prediction,OATP1B1
Summary: The in vivo metabolic clearance in human has been successfully predicted by using in vitro data
hepatocytes, the systematic underpredictions of in vivo clearance have been commonly observed among
excretion have been increasingly recognized as a rate-determining step in the hepatic clearance.
The AAPS Journal; Vol. 11 Number 2, Jun 2009;Published Date:05/31/2009; DOI: 10.1208/s12248-009-9103-6
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Author: Michael Mohutsky, Jenny Chien, Barbara Ring, Steven Wrighton
Keywords: clearance prediction,intrinsic clearance,microsomes
Summary: prediction of clearance by comparing to Km value, (2) to prove that clearance of drugs by both oxida clearance prediction; intrinsic clearance; microsomes. clearance data to in vivo clearance are known, such as
Pharmaceutical Research; Vol. 23 Number 4, Apr 2006;Published Date:03/31/2006; DOI: 10.1007/s11095-006-9663-4
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Author: Jörg Hauptmann, Torsten Steinmetzer, Helmut Vieweg, Peter Wikström, Jörg Stürzebecher
Keywords: thrombin inhibitors,structures,charged groups,systemic clearance,biliary clearance
Summary: Clearance and Biliary Excretion
duced the plasma clearance of NAPAP (8) temic clearance; biliary clearance.
Pharmaceutical Research; Vol. 19 Number 7, Jul 2002;Published Date:06/30/2002; DOI: 10.1023/A:1016426724831
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Author: Eyob Adane, Zhiwei Liu, Tian-Xiang Xiang, Bradley Anderson, Markos Leggas
Keywords: BCRP,carboxylate,lactone,OATP/Oatp,P-gp
Summary: clearances, while simulations assessed the impact of clearance
Results Our modeling showed that carboxylate clearance was
lactone clearance only, but rifampin decreased both lactone
Pharmaceutical Research; Vol. 27 Number 7, Jul 2010;Published Date:06/30/2010; DOI: 10.1007/s11095-010-0137-3
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Author: Tetsu Kajikawa, Hiromu Mishima, Teruo Murakami, Mikihisa Takano
Keywords: P-glycoprotein,ocular clearance,blood-aqueous barrier,rhodamine 123,quinidine,cyclosporin A
Summary: Ocular Clearance of Rho-123 In Vivo
Two clearance systems, aqueous humor outflow-mediated
clearance and systemic clearance by the highly vascular tissues
Pharmaceutical Research; Vol. 17 Number 4, Apr 2000;Published Date:03/31/2000; DOI: 10.1023/A:1007593407570
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Author: David Hallifax, Joanne Foster, J. Houston
Keywords: clearance,hepatocytes,human,microsomes,prediction
Summary: KEY WORDS clearance Methods A database of published predictions of clearance
CLint intrinsic clearance
Pharmaceutical Research; Online First;Published Date:07/26/2010; DOI: 10.1007/s11095-010-0218-3
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Author: Gary Thompson, Roger Toothaker
Keywords: bioavailability,nonlinear renal clearance,systemic exposure,urinary excretion
Summary: nonlinear renal clearance (saturable secretion) clearance, and linear non-renal clearance was assumed (Fig. clearance, CL is the filtration clearance via the kidney, C is
Pharmaceutical Research; Vol. 21 Number 5, May 2004;Published Date:04/30/2004; DOI: 10.1023/B:PHAM.0000026428.48103.4f
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Author: Helen Cubitt, J. Houston, Aleksandra Galetin
Keywords: clearance prediction,glucuronidation,intestine
Summary: on glucuronidation clearance prediction. CLint for the prediction of in vivo clearance was assessed. intrinsic clearance by glucuronidation; CLint,CYP, intrinsic clearance
Pharmaceutical Research; Vol. 26 Number 5, May 2009;Published Date:04/30/2009; DOI: 10.1007/s11095-008-9823-9
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