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Author: Kavitha Koushik, Gangadhar Sunkara, Peter Gwilt, Uday Kompella
Keywords: deslorelin,Calu-1 cells,degradation pathways,membrane, cytosol
Summary: kinetics of degradation of deslorelin, pGlu1-His2-Trp3-Ser4-Tyr5-D- zymatic degradation of peptide drugs has been to use cyclo- for deslorelin degradation and the formation of degradation products
Pharmaceutical Research; Vol. 20 Number 5, May 2003;Published Date:04/30/2003; DOI: 10.1023/A:1023489620394
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Author: Neera Jain, Stephen Machatha, S. Tabibi, Samuel Yalkowsky
Keywords: Stability,RH1,solubility,degradation,mechanism
Summary: Stability, RH1, solubility, degradation, et al4 who studied the degradation products of RH1. degradation of RH1 is of concern because it is intended to
AAPS PharmSciTech; Vol. 8 Number 1, Mar 2007;Published Date:02/28/2007; DOI: 10.1208/pt0801016
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Author: Florentine Nieuwmeyer, Kees Voort Maarschalk, Herman Vromans
Keywords: degradation,lactose,particle surface,phosphate,steroid
Summary: known to occur, leading to increased rate of chemical degradation. Small lactose particles lead to a higher degree of degradation. Degradation was enhanced under
Pharmaceutical Research; Vol. 25 Number 11, Nov 2008;Published Date:10/31/2008; DOI: 10.1007/s11095-008-9687-z
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Author: Bojan Jankovi
Keywords: degradation,drug stability,folic acid,Folnak®,nonisothermal kinetics
Summary: The nonisothermal degradation process of Folnak� drug samples was investigated by
that the degradation proceeds through the five degradation
During degradation, all excipients increase their thermal stability, and some kind of solid�
AAPS PharmSciTech; Vol. 11 Number 1, Mar 2010;Published Date:02/28/2010; DOI: 10.1208/s12249-009-9363-6
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Author: Andrea Hawe, Robert Poole, Stefan Romeijn, Piotr Kasper, Rob Heijden, Wim Jiskoot
Keywords: aggregation,Arrhenius kinetics,degradation,mass spectrometry,oxytocin
Summary: and Identification of Degradation Products
To investigate degradation kinetics of oxytocin as a function of temperature and pH, and
identify the degradation products.
Pharmaceutical Research; Vol. 26 Number 7, Jul 2009;Published Date:06/30/2009; DOI: 10.1007/s11095-009-9878-2
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Author: Ashley Hawkins, Nitin Satarkar, J. Hilt
Keywords: degradable polymers,drug release,hydrogels,nanocomposite,remote control
Summary: To demonstrate remote controlled degradation of degradable nanocomposite hydrogels by
particles into a degradable hydrogel that exhibited temperature dependent degradation. degradation, and drug release studies were conducted by application of an AMF to determine if
Pharmaceutical Research; Vol. 26 Number 3, Mar 2009;Published Date:02/28/2009; DOI: 10.1007/s11095-008-9804-z
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Author: Wade Demond, Richard Kenley, James Italien, David Lokensgard, G. Weilersbacher, Keith Herman
Keywords: Pramlintide,Peptide Analysis,RP-HPLC,SCX-HPLC,Orthogonal Separation,Diastereoselectivity
Summary: as degradation products of pramlintide formulated for
degradation products. determining spiked authentic samples of degradation
AAPS PharmSciTech; Vol. 1 Number 1, Mar 2000;Published Date:02/29/2000; DOI: 10.1208/pt010106
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Author: Rajiv Mahajan, Allen Templeton, Amy Harman, Robert A. Reed, Rey T. Chern
Keywords: auto-oxidation,headspace oxygen concentration,headspace relative humidity,inert atmosphere packaging,oxygen scavenger
Summary: Oxidative degradation of drug substances in pharmaceutical products is well documented and
option for reducing oxidative degradation in pharmaceutical products. degradation of a model pharmaceutical formulation.
Pharmaceutical Research; Vol. 22 Number 1, Jan 2005;Published Date:12/31/2004; DOI: 10.1007/s11095-004-9018-y
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