|
Author: Radojka Savic, Mats Karlsson
Keywords: empirical Bayes estimates,extended grid method,NONMEM,nonparametric method,parameter distribution
Summary: simulation from the parametric distribution, hence the name extended-grid method. parameter distribution. relax the parameter distribution assumption.
The AAPS Journal; Vol. 11 Number 3, Sep 2009;Published Date:08/31/2009; DOI: 10.1208/s12248-009-9138-8
|
|
Author: Klas Petersson, Eva Hanze, Radojka Savic, Mats Karlsson
Keywords: estimation,normality assumption,parameter distributions,population modeling,transformations
Summary: often erroneous assumption of a known shape of the parameter distribution. creates a truncated distribution. way of relaxing the assumption of a known distribution is to
Pharmaceutical Research; Vol. 26 Number 9, Sep 2009;Published Date:08/31/2009; DOI: 10.1007/s11095-009-9931-1
|
|
Author: Steven Novick, David Christopher, Monisha Dey, Svetlana Lyapustina, Michael Golden, Stefan Leiner, Bruce Wyka, Hans-Joachim Delzeit, Chris Novak, Gregory Larner
Keywords: bimodal,distribution,heavy-tailed,inhaler,skewed
Summary: bimodal; distribution; heavy-tailed; inhaler; skewed. DDU distribution for a typical product is studied during product
of an MDI suspension may lead to a normal distribution with
AAPS PharmSciTech; Vol. 10 Number 3, Sep 2009;Published Date:08/31/2009; DOI: 10.1208/s12249-009-9271-9
|
|
Author: Robert Fielding
Keywords: liposomes,volume of distribution,tissue distribution
Summary: 1000-fold difference in volume of distribution suggests tissue
distribution should differ markedly, yet actual tissue drug
Physiologic Distribution of Liposomal
Pharmaceutical Research; Vol. 18 Number 2, Feb 2001;Published Date:01/31/2001; DOI: 10.1023/A:1011096821662
|
|
Author: Michael Weiss
Keywords: diffusion,distribution,pharmacokinetics,residence time,tissue binding
Summary: To evaluate distribution kinetics of drugs by the relative dispersion of disposition residence
information on the distribution kinetics of drugs, i.e., diffusion-limited
distribution or slow tissue binding, without assuming a specific structural model.
Pharmaceutical Research; Vol. 24 Number 11, Nov 2007;Published Date:10/31/2007; DOI: 10.1007/s11095-007-9332-2
|
|
Author: Henryk Faas, Werner Schwizer, Christine Feinle, Hans Lengsfeld, Chris de Smidt, Peter Boesiger, Michael Fried, Thomas Rades
Keywords: intragastric drug distribution,colloidal system,liposomes,solid meal,liquid meal,magnetic resonance imaging
Summary: gamma scintigraphy to study drug distribution in the gastro- acquire three-dimensional information on the distribution of
Monitoring the distribution of drugs or drug delivery sys-
Pharmaceutical Research; Vol. 18 Number 4, Apr 2001;Published Date:03/31/2001; DOI: 10.1023/A:1011098125916
|
|
Author: Michal Krauze, John Forsayeth, John Park, Krystof Bankiewicz
Keywords: blood–brain barrier,CED,convection-enhanced delivery,direct drug delivery,liposome,MR,MRI
Summary: liposomes in CNS, and quantification of liposome distribution. volume of distribution (Vd) compared to simple diffusion. rodents, we have observed excellent distribution of liposomes
Pharmaceutical Research; Vol. 23 Number 11, Nov 2006;Published Date:10/31/2006; DOI: 10.1007/s11095-006-9103-5
|
|
Author: Anita Grover, Leslie Benet
Keywords: distribution volume,drug-drug interaction,drug transporters,pharmacokinetics,pharmacogenomics
Summary: distribution can lead to a significant change in drug effect or likelihood of toxicity, as well as a focus on the changes in distribution volume. contributor to distribution volume than the kidneys, in consideration of both uptake and efflux
The AAPS Journal; Vol. 11 Number 2, Jun 2009;Published Date:05/31/2009; DOI: 10.1208/s12248-009-9102-7
|