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Author: Lei Zhang, Yuanchao Zhang, Ping Zhao, Shiew-Mei Huang
Themed Issue: Towards Integrated ADME Prediction: Past, Present, and Future Directions
Keywords: drug development,drug–drug interaction,new drug application,prediction,regulatory and guidance
Summary: new molecular entity's drug�drug interaction potential is an integral part of drug development and
drug development; drug�drug interaction; new drug application; prediction; regulatory
Evaluation of an NME's drug�drug interaction potential is
The AAPS Journal; Vol. 11 Number 2, Jun 2009;Published Date:05/31/2009; DOI: 10.1208/s12248-009-9106-3
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Author: Corbin Bachmeier, Timothy Spitzenberger, William Elmquist, Donald Miller
Keywords: BCECF,blood–brain barrier,HIV-1 protease inhibitors
Summary: To quantitatively characterize the drug efflux interactions of various HIV-1 protease inhibitors
The rank order potency for MRP-related drug efflux
Prior studies have established an interaction
Pharmaceutical Research; Vol. 22 Number 8, Aug 2005;Published Date:07/31/2005; DOI: 10.1007/s11095-005-5271-y
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Author: Touraj Ehtezazi, Thirumala Govender, Snjezana Stolnik
Keywords: isothermal calorimetry,binding parameters,supramolecular assemblies
Summary: Interaction of a Cationic Drug with
The interaction between a drug
the mechanisms of interaction between a drug or DNA and
Pharmaceutical Research; Vol. 17 Number 7, Jul 2000;Published Date:06/30/2000; DOI: 10.1023/A:1007520628237
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Author: Laura Hinton, Aleksandra Galetin, J. Houston
Keywords: CYP2C8,drug–drug interactions,enzyme inhibition,gemfibrozil,OATP1B1
Summary: Multiple Inhibition Mechanisms and Prediction of Drug�Drug Interactions: and irreversible drug�drug interactions (DDIs) have been
inhibitor; DDI, drug�drug interactions; fmCYPi, fraction of drug
Pharmaceutical Research; Vol. 25 Number 5, May 2008;Published Date:04/30/2008; DOI: 10.1007/s11095-007-9446-6
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Author: Patrick Marsac, Sheri Shamblin, Lynne Taylor
Keywords: amorphous,crystallization,miscibility,polymers,thermodynamics
Summary: Different methods were used to estimate the Flory<Huggins interaction parameter for
systems, interaction parameters derived from melting point depression were negative indicating that
Using these interaction parameters and Flory<Huggins theory, miscibility was
Pharmaceutical Research; Vol. 23 Number 10, Oct 2006;Published Date:09/30/2006; DOI: 10.1007/s11095-006-9063-9
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Author: Patrick Marsac, Tonglei Li, Lynne Taylor
Keywords: amorphous,crystallization,miscibility,polymer
Summary: Dispersions Using Experimentally Determined Interaction Parameters
Understanding the miscibility of drug�polymer systems is of interest to
degree of interaction and the type of interaction contribute
Pharmaceutical Research; Vol. 26 Number 1, Jan 2009;Published Date:12/31/2008; DOI: 10.1007/s11095-008-9721-1
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Author: Motohiro Kato, Yoshihisa Shitara, Hitoshi Sato, Kunihiro Yoshisue, Masaru Hirano, Toshihiko Ikeda, Yuichi Sugiyama
Keywords: CYP,drug interaction,enzyme inhibition,physiologically based pharmacokinetics
Summary: The objective is to confirm if the prediction of the drug�drug interaction using a physiologically
CYP; drug interaction; enzyme inhibition; physiologically based pharmacokinetics. �drug interaction.
Pharmaceutical Research; Vol. 25 Number 8, Aug 2008;Published Date:07/31/2008; DOI: 10.1007/s11095-008-9607-2
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Author: Kiyomi Ito, Koji Chiba, Masato Horikawa, Michi Ishigami, Naomi Mizuno, Jun Aoki, Yasumasa Gotoh, Takafumi Iwatsubo, Shin-ichi Kanamitsu, Motohiro Kato, Iichiro Kawahara, Kayoko Niinuma, Akiko Nishino, Norihito Sato, Yuko Tsukamoto, Kaoru Ueda, Tomoo Itoh, Yuichi Sugiyama
Keywords: Drug interaction,metabolism,quantitative prediction
Summary: drug, the degree of in vivo interaction can be evaluated Drug interaction, metabolism, quantitative drug metabolism or drug interactions in humans from in
The AAPS Journal; Vol. 4 Number 4, Dec 2002;Published Date:11/30/2002; DOI: 10.1208/ps040425
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