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Author: Cindy Xia, Wei Yin, Vinita Uttamsingh, Hua Yang, Jason Labutti, Frank W. Lee, Liang-Shang Gan, Ping Li, Nelamangala Nagaraja, Kym Cardoza, Jing-Tao Wu, Gerald T. Miwa, Suresh K. Balani, Mark Qian, Sandeepraj Pusalkar, Chuang Lu, Ron Huang, J. Scott Daniels
Summary: Inc. Drug Metabolism and Pharmacokinetics Drug Safety and Disposition 40 Landsdowne Street Cambridg Inc. Drug Metabolism and Pharmacokinetics Drug Safety and Disposition 40 Landsdowne Street Cambridg Inc. Drug Metabolism and Pharmacokinetics Drug Safety and Disposition 40 Landsdowne Street Cambridg
; DOI: 10.1007/978-0-387-44961-6_4
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Author: Lilian Yengi, Louis Leung, John Kao
Keywords: drug discovery and development,drug interactions clearance,drug metabolism,exposure,idiosyncratic drug toxicity,inhibition,integration of emerging sciences,pharmacogenetics,pharmacogenomics,transporters
Summary: The Evolving Role of Drug Metabolism in Drug Discovery and Development
drug discovery and development; drug interactions clearance; drug metabolism; Drug Metabolism Division, Drug Safety and Metabolism, Wyeth
Pharmaceutical Research; Vol. 24 Number 5, May 2007;Published Date:04/30/2007; DOI: 10.1007/s11095-006-9217-9
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Author: Timothy Harper, Patrick Brassil
Keywords: cytochrome P450,metabolism,reaction phenotyping,UDP-glucuronosyltransferase
Summary: Defining Metabolism Properties of New Drug Candidates During Drug Discovery
Reaction phenotyping studies to identify specific enzymes involved in the metabolism of drug
in drug metabolism are known to exhibit polymorphic
The AAPS Journal; Vol. 10 Number 1, Mar 2008;Published Date:02/29/2008; DOI: 10.1208/s12248-008-9019-6
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Author: Ai-Ming Yu
Keywords: CYP2D6,drug interactions,indolealkylamine,metabolism,MAO,pharmacogenetics,tryptamine
Summary: prevention of unwanted drug�drug interactions (DDIs) CYP2D6; drug interactions; indolealkylamine; metabolism; MAO; pharmacogenetics; Metabolism and Drug�Drug Interactions of Ergotamine
The AAPS Journal; Vol. 10 Number 2, Jun 2008;Published Date:05/31/2008; DOI: 10.1208/s12248-008-9028-5
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Author: Tetsuya Aiba, Yutaka Takehara, Marie Okuno, Yukiya Hashimoto
Keywords: CYP3A4,CYP3A1,CYP3A2,intestinal metabolism,substrate specificity
Summary: Intestinal Drug Metabolism
To date, various studies on drug metabolism in intestine
The hepatic drug metabolism in rats was evaluated with
Pharmaceutical Research; Vol. 20 Number 5, May 2003;Published Date:04/30/2003; DOI: 10.1023/A:1023429401738
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Author: Leslie Benet, Gordon Amidon, Dirk Barends, Hans Lennernäs, James Polli, Vinod Shah, Salomon Stavchansky, Lawrence Yu
Keywords: BCS,BDDCS,bioequivalence,elimination pathways
Summary: We recommend that regulatory agencies add the extent of drug metabolism (i.e.,90% 8 Food and Drug Administration, Center for Drug Evaluation and
metabolism, then the drug exhibited high permeability, while
Pharmaceutical Research; Vol. 25 Number 3, Mar 2008;Published Date:02/29/2008; DOI: 10.1007/s11095-007-9523-x
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Author: Arthur Craigmill, Kristy Cortright
Keywords: food safety,residues,comparative metabolism
Summary: Residues are composed of the parent drug and metabolites, published a review of comparative food animal drug metab- must be considered when comparing drug metabolism
The AAPS Journal; Vol. 4 Number 4, Dec 2002;Published Date:11/30/2002; DOI: 10.1208/ps040434
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Author: F. Guengerich
Keywords: Cytochrome P450,drug metabolism,toxicity,reactive metabolites
Summary: drug toxicity actually involves metabolism, and we exam- Cytochrome P450 , drug metabolism , toxicity drug metabolism ( Figure 4A ), with the other major contrib-
The AAPS Journal; Vol. 8 Number 1, Mar 2006;Published Date:02/28/2006; DOI: 10.1208/aapsj080112
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